Characterization of Platelet-Releasable Forms of P-Amyloid Precursor Proteins: The Effect of Thrombin
نویسندگان
چکیده
Activated platelets release a potent inhibitor of factor Xla previously identified as a Kunitz proteinase inhibitor domaincontaining form of the p-amyloid precursor proteins (pAPP). Two carboxy-terminal truncated forms of the pAPP, pAPP751 and pAPP-770. are shown to be the predominant isoforms secreted by platelets. The release of pAPP from platelets is responsible for the higher concentration of pAPP in serum compared with plasma, and thrombin doseresponse data show that release of pAPP is most consistent with a granule localization within the platelet. Thrombin
منابع مشابه
Characterization of platelet-releasable forms of beta-amyloid precursor proteins: the effect of thrombin.
Activated platelets release a potent inhibitor of factor XIa previously identified as a Kunitz proteinase inhibitor domain-containing form of the beta-amyloid precursor proteins (beta APP). Two carboxy-terminal truncated forms of the beta APP, beta APP-751 and beta APP-770, are shown to be the predominant isoforms secreted by platelets. The release of beta APP from platelets is responsible for ...
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